Purpose: The sensitive measurement of individual cells requires that each cell pass one-by-one through a small detection volume.This module employs fluidic structures to hydrodynamically focus cells laterally into the middle of a micro-channel, and chevron patterns to push cells vertically toward the bottom of the channel.(Howell, 2008).
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Purpose: Microfluidic devices allow the controlled layering of flow streams as well as the controlled delivery of solutes into a flow stream. By sheathing a center blood flow with a viscosity-matched buffer flow on each side, small solutes like calcium ion can rapidly diffuse into the center stream, reaching a … Learn more
Purpose: Polymer microspheres and microcapsules are used ubiquitously in tissue engineering and drug delivery as drug depots and carriers. These microspheres and microcapsules are typically generated by emulsification process, followed by solidification or removal of the solvent. Majors challenges that limit the widespread utilization of these microspheres/microcapsules in clinical settings … Learn more
Purpose: Microfluidic devices allow the controlled delivery of solutes into a flow stream. Using a membrane placed between two fluidic channels, the solute delivery may include either a diffusive flux, convective flux, or intermediate, based upon control of the pore Peclet number (Neeves, 2010; Neeves, 2008).
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Purpose: Microfluidic devices allow the generation of extreme shear rates useful for the study of thrombosis in severely stenosis coronary syndromes (Colace, 2013, Colace, 2013, Colace, 2012). In assisted circulation pumps such as left ventricle assist devices (LVADs), extreme shear rates can cause depletion of von Willebrand factor (vWF), hemolysis, … Learn more
Purpose: Microfluidic devices allow the generation of flow fields and localized control of pressure drops across porous matrix or cellular assemblies (Muthard, 2012). These devices have been used to measure endothelial migration and angiogenesis, blood clot permeability, clot retraction, and inner clot reaction dynamics (Muthard, 2013). The design is especially … Learn more
Purpose: Microfluidic devices have emerged as an essential tool in the study of blood coagulation. (Colace, 2013) An 8-channel device has been developed that allows the simultaneous delivery of eight individual fluid samples (such as human whole blood treated with various agents) over a patterned feature of protein matrix such … Learn more