Side view thrombosis microfluidic device with controllable wall shear rate and transthrombus pressure gradient

Side view thrombosis microfluidic device with controllable wall shear rate and transthrombus pressure gradient

Muthard RW, Diamond SL. Side view thrombosis microfluidic device with controllable wall shear rate and transthrombus pressure gradient. Lab Chip May 21 2013; 13 (10): 1883-1891.

Hemodynamic conditions vary throughout the vasculature, creating diverse environments in which platelets must respond. To stop bleeding, a growing platelet deposit must … Learn more

Microfluidic focal thrombosis model for measuring murine platelet deposition and stability

Collagen patterning and blood flow device

Neeves KB, Maloney SF, Fong KP, Schmaier AA, Kahn ML, Brass LF, Diamond SL. Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates. J Thromb Haemost Dec 2008; 6 (12): 2193-2201.

Objective: To measure murine platelet deposition and stability in … Learn more

Microfluidic device for constant flowrate or constant transmural pressure gradients (Diamond, SL)

(A) Microfluidic that allows perfusion from an inlet (Q1) over a collagen plug held on a micropost array (B) to allow a constant pressure drop (and fluid permeation) across the collagen).  PDMS device shown at time of use with 3 pressure sensors and two infusion ports connected (C).

Purpose: Microfluidic devices allow the generation of flow fields and localized control of pressure drops across porous matrix or cellular assemblies (Muthard, 2012).  These devices have been used to measure endothelial migration and angiogenesis, blood clot permeability, clot retraction, and inner clot reaction dynamics (Muthard, 2013).  The design is especially … Learn more