Purpose: The sensitive measurement of individual cells requires that each cell pass one-by-one through a small detection volume.This module employs fluidic structures to hydrodynamically focus cells laterally into the middle of a micro-channel, and chevron patterns to push cells vertically toward the bottom of the channel.(Howell, 2008).
Method of Fabrication/Use: … Learn more
Purpose: Microfluidic devices allow the generation of extreme shear rates useful for the study of thrombosis in severely stenosis coronary syndromes (Colace, 2013, Colace, 2013, Colace, 2012). In assisted circulation pumps such as left ventricle assist devices (LVADs), extreme shear rates can cause depletion of von Willebrand factor (vWF), hemolysis, … Learn more
Purpose: Microfluidic devices allow the generation of flow fields and localized control of pressure drops across porous matrix or cellular assemblies (Muthard, 2012). These devices have been used to measure endothelial migration and angiogenesis, blood clot permeability, clot retraction, and inner clot reaction dynamics (Muthard, 2013). The design is especially … Learn more