Membrane microfluidic device for controlled flux delivery into a flow stream

Microfluidic device for control delivery of solutes into a flow stream. (A) The device consisted of two perpendicular channels in PDMS separated by a polycarbonate membrane. The two PDMS layers are reversibly sealed using vacuum assisted bonding. (B) At the intersection of the two channels, the flux of the agonist molecules was controlled by the pore size and transmembrane pressure. The transmembrane pressure was manipulated by varying the relative flow rate (Q1/Q2) between the top and bottom channels. (C) Electron micrograph of the bottom channel and posts in the vacuum chamber, which provided mechanical support during operation.

Purpose: Microfluidic devices allow the controlled delivery of solutes into a flow stream.  Using a membrane placed between two fluidic channels, the solute delivery may include either a diffusive flux, convective flux, or intermediate, based upon control of the pore Peclet number (Neeves, 2010; Neeves, 2008).

Method of Fabrication/Use: This … Learn more