Lung-on-a-chip device (Huh, D)

Lung-on-a-chip microfluidics.  This device allows simultaneous control of fluid perfusion over an endothelium, exposure of air to the pulmonary epithelium at an air-liquid culture condition and independent control of the stretch of the epithelium and endothelium, thereby fully recreating the complex environment of alveolar inflation mechanics during lung inflation.  The device has broad use with respect to the understanding of acute lung injury, chronic obstructive pulmonary disease (COPD), respirator injury and respirator design, pulmonary embolism, lung inflammation and asthma.

Organ-like surrogates can be created using microfluidic devices to recreate air-liquid interfaces, cell-cell communication and complex tissue mechanics.  Such “organ-on-a-chip” devices are powerful tools to study a functional alveolar-capillary interface, relevant to infection, inflammation, and lung dysfunction and acute lung injury.

The upper and lower layers of the microfluidic device … Learn more